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Effects of suramin on cell-cycle kinetics of MCF-7 human breast cancer cells in vitro.

機(jī)譯：蘇拉明對(duì)MCF-7人乳腺癌細(xì)胞體外細(xì)胞周期動(dòng)力學(xué)的影響。

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摘要

The polyanionic compound suramin can inhibit the proliferation of cells of various origin, including from breast cancer. We have studied the effects of suramin on cell cycle kinetics and distribution of MCF-7 human breast cancer cells in vitro. It was found that both under serum-containing and serum-free culture conditions, and in the absence or presence of oestradiol or insulin-like growth factor-1, prolonged exposure (> or = 48 h) to suramin caused an accumulation of surviving cells in the G2/M-phase of the cell cycle. At a concentration of more than 100 micrograms ml-1 suramin significantly inhibited cell proliferation. The observed effects of suramin on breast cancer cells in vitro, i.e. antiproliferative effects and accumulation of cells in the G2/M-phase of the cell cycle, may have beneficial consequences in the application of treatment strategies based on a combination of suramin with cell cycle specific drugs or radiation therapy.
機(jī)譯：聚陰離子化合物蘇拉明可以抑制各種來(lái)源的細(xì)胞增殖，包括乳腺癌細(xì)胞。我們已經(jīng)研究了蘇拉明對(duì)體外MCF-7人乳腺癌細(xì)胞的細(xì)胞周期動(dòng)力學(xué)和分布的影響。發(fā)現(xiàn)在含血清和無(wú)血清培養(yǎng)條件下，以及在不存在或存在雌二醇或胰島素樣生長(zhǎng)因子-1的情況下，長(zhǎng)時(shí)間暴露于蘇拉明（>或= 48 h）都會(huì)導(dǎo)致存活細(xì)胞的積累在細(xì)胞周期的G2 / M期。當(dāng)濃度超過(guò)100微克時(shí)，ml-1蘇拉明明顯抑制細(xì)胞增殖。蘇拉明在體外對(duì)乳腺癌細(xì)胞的作用，即在細(xì)胞周期的G2 / M期的抗增殖作用和細(xì)胞蓄積，可能對(duì)基于蘇拉明與細(xì)胞周期結(jié)合的治療策略的應(yīng)用產(chǎn)生有益的影響特定藥物或放射療法。

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